So wie es aussieht, und wenn ich das alles richtig verstanden habe, haben Wissenschaftler eine Möglichkeit gefunden Katzen gegen die feline Variante von HIV zu immunisieren in dem man ihnen ein bestimmtes Gen injiziert, dessen Aktivierung erst durch ein bestimmtes Quallen-Gen sichtbar gemacht wird, welches die Katzen im Dunkeln leuchten lässt!
The technique is called gamete-targeted lentiviral transgenesis — essentially, inserting genes into feline oocytes (eggs) before sperm fertilization. Succeeding with it for the first time in a carnivore, the team inserted a gene for a rhesus macaque restriction factor known to block cell infection by FIV, as well as a jellyfish gene for tracking purposes.
Oder etwas bekömmlicher vom Discover Magazine aufbereitet:
When these green kitties were still twinkles in their parents’ eyes, scientists investigating a macaque gene thought to protect monkeys against feline immunodeficiency virus (FIV) inserted it into cat eggs with a lab-grown virus, intending to test whether cats carrying the gene were resistant to FIV as well. Researchers are interested in seeing how the macaque gene guards against FIV, which is the feline version of HIV, in hopes of transferring their insights to combating HIV.
But here’s where things get wacky: The team also included in the virus a jellyfish gene that makes a glowing green protein, to act as a signal. The virus does not always succeed in transferring the genes entrusted to it, but by including the jellyfish gene, the team gave themselves an easy way to tell when the transfer took place: kittens that glow green under fluorescent light, showing that they carry the jellyfish gene, almost certainly carry the macaque gene as well.